Energy and fatigue
For people who feel run down and want to support how their cells make energy.
Physician-prescribed · San Francisco telehealth
NAD+ is a coenzyme your cells use to make energy, and levels tend to fall with age. Find out what NAD+ injections are, how they compare with IV therapy and whether they may fit your goals, starting with a free telehealth consult.
The basics
NAD+, or nicotinamide adenine dinucleotide, is a coenzyme found in every cell of your body. Cells use it to turn the food you eat into usable energy.
NAD+ also supports enzymes involved in DNA repair and in how cells respond to stress, including a family of proteins called sirtuins. Your body constantly uses and rebuilds its supply.
Research has found that NAD+ levels tend to fall as we age. That is the main reason NAD+ has drawn so much interest, and why people ask about ways to support their levels.
NAD+ is not a peptide, but it is part of our peptide therapy program because patients often ask about them together.
Common reasons
Here are the goals patients most often bring up. Researchers continue to study NAD+ in these areas, and individual results vary.
For people who feel run down and want to support how their cells make energy.
For people interested in focus, clarity and brain health.
For people thinking long term about how they age.
For active people who want to support training and recovery.
For people working on weight, blood sugar or overall metabolism.
For people who want a physician's view on whether NAD+ makes sense for them.
Most human studies so far have looked at NAD+ precursors such as NR and NMN, usually taken by mouth. Those studies report that they raise NAD+-related markers and are generally well tolerated over weeks to months. Research on injected NAD+ is ongoing.
Feeling exhausted all the time? Ongoing fatigue can have medical causes, such as thyroid problems, anemia or sleep apnea. Tell us about it at your consult so it can be looked at properly.
Your options
There is more than one way to take NAD+ or support your levels. Here is how the most common options compare.
What we offer
At an infusion clinic
Over the counter
What to expect
Choose a time online. Your telehealth consult has no cost and no obligation.
By telehealth, you go over your goals and whether NAD+ may fit. Then you complete a short intake with your health history and medications.
Dr. Crystal Broussard, M.D. reviews your intake, orders labs only if needed, and decides whether NAD+ is appropriate.
If prescribed, NAD+ ships to your home from a pharmacy. Dr. Broussard provides instructions for your dose and schedule.

Your physician
Dr. Crystal Broussard, M.D. is board certified in internal medicine and specializes in functional medicine, anti-aging and weight management. She is licensed in all 50 states.
She reviews your intake, decides whether NAD+ is appropriate, sets your dose and schedule, and adjusts your plan over time. If NAD+ is not right for you, she will tell you.
Safety
Commonly reported effects include nausea, flushing or warmth, headache, dizziness, and redness, bruising or discomfort at the injection site. Rarely, a firm lump can form where you injected.
Call 911 for trouble breathing, swelling of the face or throat, chest pain or a severe reaction.
NAD+ injections are compounded for individual patients by prescription. Compounded medications are not FDA-approved. Your physician will explain what that means before you decide.
Be careful buying NAD+ online. Injectable products sold without a medical review give you no way to verify what you are getting.
Related care
FAQs
NAD+ injections deliver nicotinamide adenine dinucleotide, a coenzyme found in every cell, by a small shot under the skin. At TruSpine, NAD+ is prescribed by a physician when appropriate and shipped to your home.
Book a free telehealth consult with Dr. Supreet Shah. After your consult you complete a short intake, and Dr. Crystal Broussard, M.D. reviews it and decides whether NAD+ is appropriate for you.
Injectable NAD+ is prepared by a compounding pharmacy for an individual patient and should be used under the care of a licensed prescriber. Be cautious of websites that sell injectable NAD+ without a medical review.
No. Compounded NAD+ is not an FDA-approved drug. As of FDA's most recent published list, NAD is among the substances under evaluation for use in compounding. Dr. Broussard will explain what that means before you decide.
It varies by prescriber and by patient. Many schedules start with injections one to three times a week and are adjusted over time. Dr. Broussard sets your dose and schedule.
Yes, if it is prescribed for you. NAD+ is commonly given as a small injection under the skin, and Dr. Broussard provides instructions for doing it at home.
It varies. Some people say they notice changes in energy within a few weeks, and others notice little. Dr. Broussard will help you decide when to reassess, so you are not continuing something that is not helping.
The most commonly reported are nausea, flushing or warmth, headache, dizziness, and redness, bruising or discomfort at the injection site. They are usually temporary and often relate to the dose. Rarely, a firm lump can form at the injection site. Tell your provider about anything unusual.
Side effects, cost, and the fact that it is a compounded medication rather than an FDA-approved one are the main considerations. Results also vary from person to person. We will talk through all of this at your free consult.
That depends on your goals and your health. Dr. Broussard can help you decide whether it makes sense for you, and whether something else should be looked at first. If your fatigue has a medical cause, finding that comes first.
It depends on your dose and schedule. We will go over the exact cost during your free consult, before you decide anything. Insurance usually does not cover NAD+ therapy.
They are different. IV NAD+ is given slowly at a clinic over a longer visit. Injections are shorter and can be done at home. Dr. Broussard can talk through what fits your needs. Our NAD+ program is home-based rather than an IV infusion.
NAD+ is the coenzyme your cells use. NMN and NR are precursors, meaning your body can convert them into NAD+. NMN and NR are usually taken by mouth, while NAD+ is usually given by injection or IV.
No. Ozempic is a brand of semaglutide, a GLP-1 medication prescribed for specific conditions. NAD+ is a coenzyme involved in cellular energy. If weight is your main goal, see our medical weight loss program.
No. NAD+ is a coenzyme, but it is often discussed alongside peptides, so we include it in our peptide therapy program.
It is generally not appropriate during pregnancy or breastfeeding. Tell your physician if you have now or have had cancer, if you have heart disease or a clotting risk, or if you take prescription medications.
This page is for general information and is not medical advice. Prescriptions are issued only when a physician determines they are appropriate. Compounded medications are not FDA-approved. Individual results vary.
Book a free telehealth consult. There is no cost and no obligation, and you can do it from home.